Does unequal alpha distribution make sense? [Two-Stage / GS Designs]

posted by Dr_Dan  – Germany, 2015-05-19 10:29 (3552 d 22:13 ago) – Posting: # 14853
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Dear all
There are some People who recommend to use a very small alpha in the first stage and a large alpha in the next.

Stage I:  0.001 leading to 99.8% CI
Stage II: 0.049 leading to 90.2% CI

Chance of approval in the first go is low, but you will have a comfortable CI in the second stage. However, as I learned from our famous captain, it is almost impossible to argue that it makes a practical difference. Do you agree or disagree? What is your experience?
Looking forward to your valuable input
Kind regards
Dr_Dan

Kind regards and have a nice day
Dr_Dan

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