CVinter (or CVtotal) from CVintra [Power / Sample Size]

posted by john john – Spain, 2015-05-14 14:16 (3566 d 03:15 ago) – Posting: # 14815
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Hi Helmut

In a bioavailability study with six healthy volunteers:

...(Cmax; range 135–422 ng ml-') and time to maximum (tmax; range 1.5–7.0 h) for the three tablet doses showed significant differences between subjects (P <0.009; between subject coefficients of variation (CVs) 34% and 27%, respectively). There were no within subject differences in C, (P = 0.32; mean within subject CV 11%

To calculate the sample size for a parallel study I use the total CV= 45?

or do I need the pooled variability? Which is?

Thanks


Edit: Merged with a later post. Don’t fork; you can edit your post with 24 hours. [Helmut]

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