CVinter (or CVtotal) from CVintra [Power / Sample Size]
Hi Helmut
In a bioavailability study with six healthy volunteers:
...(Cmax; range 135–422 ng ml-') and time to maximum (tmax; range 1.5–7.0 h) for the three tablet doses showed significant differences between subjects (P <0.009; between subject coefficients of variation (CVs) 34% and 27%, respectively). There were no within subject differences in C, (P = 0.32; mean within subject CV 11%
To calculate the sample size for a parallel study I use the total CV= 45?
or do I need the pooled variability? Which is?
Thanks
Edit: Merged with a later post. Don’t fork; you can edit your post with 24 hours. [Helmut]
In a bioavailability study with six healthy volunteers:
...(Cmax; range 135–422 ng ml-') and time to maximum (tmax; range 1.5–7.0 h) for the three tablet doses showed significant differences between subjects (P <0.009; between subject coefficients of variation (CVs) 34% and 27%, respectively). There were no within subject differences in C, (P = 0.32; mean within subject CV 11%
To calculate the sample size for a parallel study I use the total CV= 45?
or do I need the pooled variability? Which is?
Thanks
Edit: Merged with a later post. Don’t fork; you can edit your post with 24 hours. [Helmut]
Complete thread:
- Extrapolation john john 2015-05-13 13:36 [Power / Sample Size]
- CVinter (or CVtotal) from CVintra Helmut 2015-05-13 14:33
- CVinter (or CVtotal) from CVintra nobody 2015-05-13 14:53
- OT: Drug Res Helmut 2015-05-13 15:11
- OT: Drug Res nobody 2015-05-13 15:18
- completely OT Helmut 2015-05-13 15:29
- completely OT nobody 2015-05-13 15:37
- completely OT Helmut 2015-05-13 15:29
- OT: Drug Res nobody 2015-05-13 15:18
- OT: Drug Res Helmut 2015-05-13 15:11
- CVinter (or CVtotal) from CVintrajohn john 2015-05-14 12:16
- CVtotal ≠ CVintra + CVinter Helmut 2015-05-15 13:05
- CVtotal ≠ CVintra + CVinter john john 2015-05-15 13:13
- CVtotal ≠ CVintra + CVinter Helmut 2015-05-15 13:14
- CVtotal ≠ CVintra + CVinter john john 2015-05-15 13:50
- CVtotal ≠ CVintra + CVinter Helmut 2015-05-15 14:07
- CVtotal ≠ CVintra + CVinter john john 2015-05-15 15:07
- CVtotal ≠ CVintra + CVinter Helmut 2015-05-15 15:10
- CVtotal ≠ CVintra + CVinter john john 2015-05-15 15:07
- CVtotal ≠ CVintra + CVinter Helmut 2015-05-15 14:07
- CVtotal ≠ CVintra + CVinter john john 2015-05-15 13:50
- CVtotal ≠ CVintra + CVinter Helmut 2015-05-15 13:14
- CVtotal ≠ CVintra + CVinter john john 2015-05-15 13:13
- CVtotal ≠ CVintra + CVinter Helmut 2015-05-15 13:05
- CVinter (or CVtotal) from CVintra nobody 2015-05-13 14:53
- CVinter (or CVtotal) from CVintra Helmut 2015-05-13 14:33