CVinter (or CVtotal) from CVintra [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2015-05-13 16:33 (3707 d 12:01 ago) – Posting: # 14804
Views: 13,094

Hi John John,

❝ Knowing the intrasubject variability is there any way to extrapolate the intersubject variability?


No. There is no relationship between those. For examples see the end of this post. Please forget CVinter. In planning a crossover study you need CVintra and for a parallel study CVtotal.

[image]In 2012 I reviewed a manuscript claiming such a relationship (well: The other way ’round – estimating CVintra from CVtotal). All [sic] reviewers rejected the manuscript.
Obviously the authors were more successful in a journal with a lower impact factor… I think that it’s crap, but if you want to have a look:

Ramírez E, Abraira V, Guerra P, Borobia AM, Duque B, López JL, Mosquera B, Lubomirov R, Carcas AJ, Frías J. A Preliminary Model to Avoid the Overestimation of Sample Size in Bioequivalence Studies. Drug Res. 2013;63(2):98–103. doi:10.1055/s-0032-1333296.


Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
23,427 posts in 4,929 threads, 1,679 registered users;
31 visitors (0 registered, 31 guests [including 9 identified bots]).
Forum time: 04:35 CEST (Europe/Vienna)

No matter what side of the argument you are on,
you always find people on your side
that you wish were on the other.    Thomas Berger

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5