CVinter (or CVtotal) from CVintra [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2015-05-13 16:33 (3567 d 03:53 ago) – Posting: # 14804
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Hi John John,

❝ Knowing the intrasubject variability is there any way to extrapolate the intersubject variability?


No. There is no relationship between those. For examples see the end of this post. Please forget CVinter. In planning a crossover study you need CVintra and for a parallel study CVtotal.

[image]In 2012 I reviewed a manuscript claiming such a relationship (well: The other way ’round – estimating CVintra from CVtotal). All [sic] reviewers rejected the manuscript.
Obviously the authors were more successful in a journal with a lower impact factor… I think that it’s crap, but if you want to have a look:

Ramírez E, Abraira V, Guerra P, Borobia AM, Duque B, López JL, Mosquera B, Lubomirov R, Carcas AJ, Frías J. A Preliminary Model to Avoid the Overestimation of Sample Size in Bioequivalence Studies. Drug Res. 2013;63(2):98–103. doi:10.1055/s-0032-1333296.


Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
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