Hydroxychloroquine [Power / Sample Size]
Hi John(s),
I guess you mean CVtotal? CVinter is only accessible in a crossover study. BE studies of hydroxychloroquine are performed in a parallel design due to its long half-life.
In the future please
first.
If the CV was not given, I calculated it from the CIs and sample sizes:
Liu’s CVs are simply bizarre. Unbelievable that such a paper passed the peer-review.
❝ I'm looking for the inter-subject variability of the Cmax of oral hydroxychloroquine.
I guess you mean CVtotal? CVinter is only accessible in a crossover study. BE studies of hydroxychloroquine are performed in a parallel design due to its long half-life.
In the future please

If the CV was not given, I calculated it from the CIs and sample sizes:
Ref. n PK metric PE 90% CI CVtotal
1 72 Cmax 97.1% 86.4–109.2% 29.8%
AUClast* 94.3% 84.2–105.7% 29.0%
2 72 Cmax 90.8% 79.3–104% 35.6%
AUC0-72 99.5% 87.4–113% 33.6%
3 54 Cmax 99.3% 98.1–102.1% 4.4%
AUC0-24 99.7% 98.9–101.4% 2.7%
Liu’s CVs are simply bizarre. Unbelievable that such a paper passed the peer-review.
- Blood was harvested for 11 weeks.
- Midha KK, Rawson MJ, Hubbard JW. Bioequivalence: Issues and Options. J Pharmacokin Biopharm. 1997;25(6):743–52.
- MHRA. Public Assessment Report: Hydroxychloroquine Sulphate 200mg Film-Coated Tablets. PL 17907/0017 (2007)
online
- Liu YM et al. A Parallel Design Study to Assess the Bioequivalence of Generic and Branded Hydroxychloroquine Sulfate Tablets in Healthy Volunteers. Arzneim Forsch / Drug Res. 2012;62(12):644–9. doi:10.1055/s-0032-1329962.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- CV inter-subject john john 2015-05-06 12:16 [Power / Sample Size]
- HydroxychloroquineHelmut 2015-05-06 13:18
- Hydroxychloroquine john john 2015-05-06 13:28
- pooled / total CV Helmut 2015-05-06 15:40
- Hydroxychloroquine nobody 2015-05-06 17:50
- Lousy review process Helmut 2015-05-06 18:21
- Lousy review process nobody 2015-05-06 18:47
- Lousy review process Helmut 2015-05-06 18:50
- Lousy review process nobody 2015-05-06 18:57
- Lousy review process Helmut 2015-05-06 18:50
- Lousy review process nobody 2015-05-28 15:53
- Lousy review process Helmut 2015-05-28 16:00
- Lousy review process nobody 2015-05-28 16:10
- Lousy review process Helmut 2015-05-28 16:00
- Lousy review process nobody 2015-05-06 18:47
- Lousy review process Helmut 2015-05-06 18:21
- Hydroxychloroquine john john 2015-05-06 13:28
- HydroxychloroquineHelmut 2015-05-06 13:18