Bioequivalence and Bioavailability Forum

Suitable code for suit­able adjusted α [Two-Stage / GS Designs]

posted by d_labes  – Berlin, Germany, 2014-06-02 10:28 (4038 d 15:39 ago) – Posting: # 13025
Views: 12,267

Dear Helmut!


Thanks for sharing this code!

Just one minor comment or better question:
How is your experience in regulatory acceptance of Potvin's 'acceptable' alpha-inflation of 0.052? If I remember correctly there was some rumour that even a smaller value of the empirical alpha has to be seen as inflation. That would mean that we had to down weight the adj. alpha to some extent.

Complete thread:

• How to find a suit­able adjusted α? Helmut 2014-05-31 18:20 [Two-Stage / GS Designs] 
  • Suitable code for suit­able adjusted αd_labes 2014-06-02 08:28
    • Handling inflation Helmut 2014-06-02 14:44
    • Potvin revis(it)ed Helmut 2014-06-02 22:07
      • Potvin revis(it)ed d_labes 2014-06-03 08:47
        • Montague revis(it)ed Helmut 2014-06-03 13:49
        • Pocock’s “natural constant” Helmut 2014-10-13 14:53
          • Pocock’s “natural constant” ElMaestro 2014-10-13 15:30
          • Another “natural constant”? d_labes 2014-10-14 08:56
            • Λ Helmut 2014-10-14 13:36