Bioequivalence and Bioavailability Forum • PowerTOST and Sample size estimation for R-SABE

PowerTOST and Sample size estimation for R-SABE [RSABE / ABEL]

posted by kumarnaidu – Mumbai, India, 2014-04-19 08:04 (4453 d 08:36 ago) – Posting: # 12860
Views: 18,992

Thanks Dr_Dan for your valuable comments.
My concern is just the number of dropouts they have kept. And according to me we should give priority to our in-house data for sample size estimation not published literature. Because the power of the study will ultimately suffer if the observed CV > assumed CV and this is same as getting more dropouts than assumed.

—
Kumar Naidu

Complete thread:

Sample size calculation for R-SABE Lucas 2014-02-07 11:41 [RSABE / ABEL]
- EMA’s ABEL Helmut 2014-02-07 14:21
  - EMA’s ABEL Lucas 2014-02-07 16:49
    - Carry-over Helmut 2014-02-07 17:12
      - Carry-over Lucas 2014-02-07 17:42
        
        Carry-over Shuanghe 2014-02-10 17:11
- PowerTOST and Sample size estimation for R-SABE d_labes 2014-02-07 14:37
  - PowerTOST and Sample size estimation for R-SABE kumarnaidu 2014-04-18 13:38
    - PowerTOST and Sample size estimation for R-SABE Dr_Dan 2014-04-18 19:29
      - PowerTOST and Sample size estimation for R-SABEkumarnaidu 2014-04-19 06:04
  - PowerTOST and Sample size estimation for R-SABE Astea 2015-06-25 01:14
    - Sample size for scABEL/RSABE vs. conventional ABE d_labes 2015-06-25 09:19
    - PowerTOST and Sample size estimation for R-SABE mittyri 2015-06-25 10:43
      - PowerTOST and Sample size estimation for R-SABE Astea 2015-06-25 13:54
        
        Scaled ABE d_labes 2015-06-25 14:04