Bioequivalence and Bioavailability Forum • N=24 or N=27

N=24 or N=27 [Power / Sample Size]

posted by d_labes – Berlin, Germany, 2013-10-18 16:34 (4629 d 18:14 ago) – Posting: # 11698
Views: 17,382

Hi Helmut,

❝ 24 is correct...

As we know: the two Laszlo's have simulated with 1E04 (10 000) sims for run-time reasons. A little bit too low I think.

[nitpicking]


sampleN.RSABE(CV=0.3, theta0=0.95, design="2x3x3", nsims=1e4, setseed=T, print=F, details=F)

  Design alpha CVwT CVwR theta0 theta1 theta2 Sample size Achieved power Target power nlast

1  2x3x3  0.05  0.3  0.3   0.95    0.8   1.25          27         0.8455          0.8    27

sampleN.RSABE(CV=0.3, theta0=0.95, design="2x3x3", nsims=1e4, setseed=F, print=F, details=F)

  Design alpha CVwT CVwR theta0 theta1 theta2 Sample size Achieved power Target power nlast

1  2x3x3  0.05  0.3  0.3   0.95    0.8   1.25          27         0.8372          0.8    27

# next tries:

1  2x3x3  0.05  0.3  0.3   0.95    0.8   1.25          27         0.8457          0.8    27

1  2x3x3  0.05  0.3  0.3   0.95    0.8   1.25          27         0.8386          0.8    27

1  2x3x3  0.05  0.3  0.3   0.95    0.8   1.25          27         0.836           0.8    27

1  2x3x3  0.05  0.3  0.3   0.95    0.8   1.25          24         0.8021          0.8    24

1  2x3x3  0.05  0.3  0.3   0.95    0.8   1.25          27         0.8417          0.8    27

1  2x3x3  0.05  0.3  0.3   0.95    0.8   1.25          24         0.8022          0.8    24

1  2x3x3  0.05  0.3  0.3   0.95    0.8   1.25          27         0.8455          0.8    27

1  2x3x3  0.05  0.3  0.3   0.95    0.8   1.25          27         0.8372          0.8    27

1  2x3x3  0.05  0.3  0.3   0.95    0.8   1.25          27         0.8457          0.8    27

1  2x3x3  0.05  0.3  0.3   0.95    0.8   1.25          27         0.8386          0.8    27

[/nitpicking]

Try this with 1E05 (100 000) sims. I up to now was not able to see N=24 (more then 100 tries). :cool:

Have a nice weekend.

—
Regards,

Detlew

Complete thread:

sample size for partial replicate - USFDA niraj.bhatt 2013-10-17 08:53 [Power / Sample Size]
- sample size for partial replicate - USFDA jag009 2013-10-17 15:09
  - sample size for partial replicate - USFDA niraj.bhatt 2013-10-18 08:18
    - Table A3 Helmut 2013-10-18 13:51
      - N=24 or N=27d_labes 2013-10-18 14:34
        
        in praise of 100,000 sim’s Helmut 2013-10-18 15:02
        N=24 or N=27 niraj.bhatt 2013-10-19 06:19
      - Table A3 niraj.bhatt 2013-10-19 06:18
- forget the partial replicate Helmut 2013-10-18 00:14
  - forget the partial replicate niraj.bhatt 2013-10-18 07:57
    - PowerTOST and RSABE d_labes 2013-10-18 11:16
  - Replicate Pilot study kumarnaidu 2014-04-11 07:37
    - Replicate Pilot study ElMaestro 2014-04-11 10:27
      - Replicate Pilot study kumarnaidu 2014-04-11 12:45
        
        Replicate Pilot study ElMaestro 2014-04-11 13:23
        
        Replicate Pilot study kumarnaidu 2014-04-14 06:22