Bioequivalence and Bioavailability Forum • Phoenix/WinNonlin

Phoenix/WinNonlin - power [Two-Stage / GS Designs]

posted by d_labes – Berlin, Germany, 2013-10-09 18:11 (4274 d 12:01 ago) – Posting: # 11635
Views: 19,686

Dear Karthik,

Additionally to Helmut's advice

❝ Again: Don’t use Phoenix/WinNonlin ...

I would like to point you to this thread which explains in the subsequent posts why you shouldn't.

It came out in this thread that the power calculated in WinNonlin is the power for a test of difference and not the power for a test of equivalence which in Bioequivalence studies has to be used.

At least in 2011 (date of the thread) this was so. As Helmut's numbers show it seems unchanged up to now.

—
Regards,

Detlew

Complete thread:

Potvin’s 2-stage adaptive design GSD 2012-08-17 20:56 [Two-Stage / GS Designs]
- Potvin’s 2-stage adaptive design + RSABE/ABEL Helmut 2012-08-18 00:39
  - Potvin’s 2-stage adaptive design + RSABE/ABEL GSD 2012-08-31 16:30
    - Tough job Helmut 2012-08-31 18:37
      - Tough job GSD 2012-08-31 19:23
        
        C/D for EMA? Good luck! Helmut 2012-09-01 15:09
      - Surprise? d_labes 2012-09-05 12:57
        
        Got it. Ages for sims to complete Helmut 2012-09-05 13:35
        
        Life belt d_labes 2012-09-05 14:51
        
        Life belt Helmut 2012-09-05 15:20
  - Power for Two stage Design K2K 2013-10-07 14:43
    - Power for Two stage Design Helmut 2013-10-07 14:59
      - Power for Two stage Design K2K 2013-10-08 14:35
        
        “Interim power” Helmut 2013-10-08 14:58
        
        “Interim power” K2K 2013-10-09 12:39
        
        Validation of PowerTOST Helmut 2013-10-09 14:10
        Phoenix/WinNonlin - powerd_labes 2013-10-09 16:11
        
        Phoenix/WinNonlin - power Helmut 2013-10-09 18:19
        
        power K2K 2013-10-10 08:36