Bioequivalence and Bioavailability Forum • Evaluation subtleties

Evaluation subtleties [RSABE / ABEL]

posted by d_labes – Berlin, Germany, 2013-08-31 19:20 (4682 d 02:21 ago) – Posting: # 11399
Views: 12,343

Dear ElMaestro,

❝ OK... lemmefink. ...

❝ Where TRT and RTR imply two different error mean squares, as you referenced earlier, I think we cannot do both TRT data and RTR data in one model if the model has only one error term.

My simulations show: Yes we can! EMA ANOVA don't show any sign of alpha inflation or too conservative type I error which one would expect if pooling is not allowed. Astonishing for me.
FDA ISC works also as long as the designs are balanced or only slightly balanced.

❝ It must be either one model with (at least) two error terms (aka. mixed) or two models with one error term in order to cover both groups.

Both nice ideas. If you have worked them out lemme know :cool:

—
Regards,

Detlew

Complete thread:

3-per, 2-trt designs and estimation of intra-subj. variance ElMaestro 2013-08-12 19:54 [RSABE / ABEL]
- 3-per, 2-trt designs and estimation of intra-subj. variance Dr_Dan 2013-08-13 10:11
  - 3-per, 2-trt designs and estimation of intra-subj. variance ElMaestro 2013-08-13 15:00
    - TRT|RTR rulez! Helmut 2013-08-13 18:23
      - TRT|RTR rulez? Really? d_labes 2013-08-14 08:16
        
        TRT|RTR rulez? Really? Yes. ElMaestro 2013-08-14 11:29
        
        TRT|RTR rulez? Really? No. d_labes 2013-08-14 13:34
        
        TRT|RTR rulez? Really? No. ElMaestro 2013-08-14 14:25
        
        TRT|RTR Lost in formulas. d_labes 2013-08-14 16:35
        
        TRT|RTR rulez? References Helmut 2013-08-14 13:44
        
        References László & László d_labes 2013-08-14 19:12
        
        Heteroscedasticity Helmut 2013-08-17 17:33
        
        Heteroscedasticity: TRT|RTR rulez! d_labes 2013-08-29 16:45
        
        Heteroscedasticity: TRT|RTR rulez! ElMaestro 2013-08-29 17:50
        
        Sims & evaluation d_labes 2013-08-30 09:16
        
        Sims & evaluation ElMaestro 2013-08-31 14:11
        
        Evaluation subtletiesd_labes 2013-08-31 17:20