Bioequivalence and Bioavailability Forum • TRT|RTR rulez? Really? Yes.

TRT|RTR rulez? Really? Yes. [RSABE / ABEL]

posted by ElMaestro – Denmark, 2013-08-14 13:29 (4701 d 12:11 ago) – Posting: # 11278
Views: 12,841

Hi d_labes,

❝ Read chapter 9.3 of Chow and Liu, especially 9.3.4 "Assessment of Intra-Subject Variabilities". And if you have, read it again.

how was the birthday? Me and 17 friends thought of partycrashing at your home but due to an unfortunate event recently involving twenty ostriches, a nuclear power station and a barrel of rum we decided against it.

I don't really get all the points of C&L. If any :-D

❝ (...) there is no valid way to evaluate T versus R in case of heteroscedasticity. And this renders the advantage useless.

Can you explain me why in words that are adapted to people with walnut-sized brains such as myself?

❝ A valid evaluation with GLM-ANOVA or even with intra-subject contrasts, which in other replicate designs is able to deal with different variabilities, has to assume s²_wT=s²_wR.

I am quite sure that it is possible to make GLM work ad modum EMA's recent adventures with fixed effects, by tampering a bit with the data sets and factor inclusions, allowing extractions of individual variances.

Anways, we are now digressing from the original topic. To which I'd still appreciate some responses. :-D

—
Pass or fail!
ElMaestro

Complete thread:

3-per, 2-trt designs and estimation of intra-subj. variance ElMaestro 2013-08-12 19:54 [RSABE / ABEL]
- 3-per, 2-trt designs and estimation of intra-subj. variance Dr_Dan 2013-08-13 10:11
  - 3-per, 2-trt designs and estimation of intra-subj. variance ElMaestro 2013-08-13 15:00
    - TRT|RTR rulez! Helmut 2013-08-13 18:23
      - TRT|RTR rulez? Really? d_labes 2013-08-14 08:16
        
        TRT|RTR rulez? Really? Yes.ElMaestro 2013-08-14 11:29
        
        TRT|RTR rulez? Really? No. d_labes 2013-08-14 13:34
        
        TRT|RTR rulez? Really? No. ElMaestro 2013-08-14 14:25
        
        TRT|RTR Lost in formulas. d_labes 2013-08-14 16:35
        
        TRT|RTR rulez? References Helmut 2013-08-14 13:44
        
        References László & László d_labes 2013-08-14 19:12
        
        Heteroscedasticity Helmut 2013-08-17 17:33
        
        Heteroscedasticity: TRT|RTR rulez! d_labes 2013-08-29 16:45
        
        Heteroscedasticity: TRT|RTR rulez! ElMaestro 2013-08-29 17:50
        
        Sims & evaluation d_labes 2013-08-30 09:16
        
        Sims & evaluation ElMaestro 2013-08-31 14:11
        
        Evaluation subtleties d_labes 2013-08-31 17:20