Bioequivalence and Bioavailability Forum • Second opinion (PHX 6.3)

Second opinion (PHX 6.3) [RSABE / ABEL]

posted by ElMaestro – Denmark, 2013-05-01 20:48 (4781 d 23:52 ago) – Posting: # 10519
Views: 29,433

Hi John,

❝ Question, what does the residual "formulation Test" represent? Is it the residual attributed to both test and ref, while residual "formulation ref" is attributed to the ref (since it was given 2x)? which one would one use to compute the 90% geometric CI then?

Can you ask SAS to spit out the covariance matrix? I mean the one corresponding to ZGZ^T+R? Then I think you can definitely interpret the variabilities in the context of the model specification.

—
Pass or fail!
ElMaestro

Complete thread:

FDA's HVD SAS Code from Progesterone Guidance jag009 2013-04-22 16:39 [RSABE / ABEL]
- Proc MIXED vs. Proc GLM Helmut 2013-04-22 17:47
  - Proc MIXED vs. Proc GLM jag009 2013-04-22 20:33
    - SAS vs. PHX Helmut 2013-04-22 22:10
      - SAS vs. PHX Shuanghe 2013-04-23 11:45
        
        SAS vs. SAS d_labes 2013-04-23 16:50
        
        SAS vs. SAS vs. Phoenix Helmut 2019-11-12 13:01
      - SAS vs. PHX jag009 2013-04-23 15:56
        
        SAS Warning (Note) on Proc Mixed jag009 2013-04-23 17:07
        
        Nut Job.. jag009 2013-04-30 21:09
        
        Second opinion (PHX 6.3) Helmut 2013-05-01 16:21
        
        Second opinion (PHX 6.3) jag009 2013-05-01 17:16
        
        Second opinion (PHX 6.3)ElMaestro 2013-05-01 18:48
        In praise of a full replicate Helmut 2013-05-01 19:16
        Third opinion d_labes 2013-05-02 12:00
        
        Compound Symmetry Helmut 2013-05-02 14:41
        
        Compound Symmetry - SASian (1) d_labes 2013-05-02 16:26
        
        Variance=0 Helmut 2013-05-03 16:07