Bioequivalence and Bioavailability Forum

2nd opinion [RSABE / ABEL]

posted by Helmut  – Vienna, Austria, 2013-04-05 03:01 (4423 d 17:18 ago) – Posting: # 10348
Views: 9,494

Hi John,

❝ The 2 GLM procedure output are different but the Ratio, 95% Upper Bound, SwRs are ok. However, my GLM procedure output for ilat analysis shows same results as those from the CRO.

OK, lacking that’s not my cup of tea.

I updated treatments and sequences in my Phoenix project (i.e., kept the full precision of your first dataset) and got:
pointest  1.5084845 
sWR       0.40266645 (CV_WR 41.96%)
critbound 0.15460335
Bad luck. Reformulate since in the unscaled analysis the lower 90% CL of 134.02% > 125.00% – demonstrating bioinequivalence.

I would opt for your analysis. Like you I got an estimate for dlat of -0.17633358 and a residual SS of 21.402516. However, these values are not further used (only the residual variance 0.32428054).

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• SAS Procedure on Partial Replicate (TRR) Study Data jag009 2013-04-02 21:11 [RSABE / ABEL] 
  • Confusing… Helmut 2013-04-03 13:42
    • Confusing… jag009 2013-04-03 16:06
      • Confusing… Helmut 2013-04-03 21:49
        • Confusing… jag009 2013-04-03 23:01
          • Confusing… Helmut 2013-04-03 23:22
            • Confusing… jag009 2013-04-04 15:59
            • Confusing… jag009 2013-04-04 17:21
              • 2nd opinionHelmut 2013-04-05 01:01
                • 2nd opinion jag009 2013-04-05 15:24
              • 3rd, 4th opinion d_labes 2013-04-05 11:04
                • 3rd, 4th opinion jag009 2013-04-05 15:41
                  • Beer swaped d_labes 2013-04-05 16:09
                    • Beer swaped jag009 2013-04-05 17:18