Bioequivalence and Bioavailability Forum • Confusing…

Confusing… [RSABE / ABEL]

posted by Helmut – Vienna, Austria, 2013-04-04 01:22 (4424 d 19:34 ago) – Posting: # 10338
Views: 9,701

Hi John!

❝ Hope this is the way you wanted (space delimited).

Not quite but I think I can handle that.

❝ I swapped the Sequence# 1,2,3 as A,B,C. Therefore sequence A=BAB (or RTR), B=ABB (or TRR), C=BBA (or RRT). A=Test, B=Reference. The columns are Subject, Period, Drug, Sequence, LnCmax. There are two missing values "."

Your coding somehow still matches the post’s subject line.*

1 1 B B 7.423568444

1 2 A B 7.70210434

1 3 B B 6.964135612

B B? Is that the reference twice? Oh no, it codes for treatment R in the 3^rd column and sequence TRR in the 4^th …

For clarity – and substituting treatments A→T, B→R and sequences A→RTR, B→TRR, C→RRT – I would have coded somefink like:

1 1 R TRR 7.423568444

1 2 T TRR 7.70210434

1 3 R TRR 6.964135612

With such a code you do not need to look at the head of the table in order to understand what is going on in each row. Much easier for error snooping …

… but hey,
1 1 R TRR 7.423568444 → R is not in period 1
1 2 T TRR 7.70210434 → T is not in period 2
1 3 R TRR 6.964135612 → OK, R is in period 3

Can you check please?

If I trust the sequences more and recode treatment according to period, e.g.,

1 1 T TRR 7.423568444

1 2 R TRR 7.70210434

1 3 R TRR 6.964135612

I got in Phoenix 6.3:
pointest 0.86899272 (passes; within [0.8, 1.25])
sWR 0.45854843 (≥0.294; perform RSABE. CV_WR 48.37%)
critbound -0.092689149 (≤0: passes RSABE)

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Complete thread:

SAS Procedure on Partial Replicate (TRR) Study Data jag009 2013-04-02 21:11 [RSABE / ABEL]
- Confusing… Helmut 2013-04-03 13:42
  - Confusing… jag009 2013-04-03 16:06
    - Confusing… Helmut 2013-04-03 21:49
      - Confusing… jag009 2013-04-03 23:01
        
        Confusing…Helmut 2013-04-03 23:22
        
        Confusing… jag009 2013-04-04 15:59
        Confusing… jag009 2013-04-04 17:21
        
        2nd opinion Helmut 2013-04-05 01:01
        
        2nd opinion jag009 2013-04-05 15:24
        
        3rd, 4th opinion d_labes 2013-04-05 11:04
        
        3rd, 4th opinion jag009 2013-04-05 15:41
        
        Beer swaped d_labes 2013-04-05 16:09
        
        Beer swaped jag009 2013-04-05 17:18