Bioequivalence and Bioavailability Forum

target α in sim’s? [RSABE / ABEL]

posted by martin  – Austria, 2013-03-27 17:36 (4449 d 00:40 ago) – Posting: # 10298
Views: 24,960

Hi Helmut!

IMHO: yes as this is a constant and should not dependent on the number of simulation runs. however, differences should be rather small by using 1E6 runs.

best regards

martin

Ps.: ... and yes its the same guy who is famous for publicly calling some approaches “bullshit”

Complete thread:

• ‘alpha’ of scaled ABE? d_labes 2013-03-15 15:56 [RSABE / ABEL] 
  • ‘alpha’ of scaled ABE? Helmut 2013-03-15 17:27
    • ’alpha’ of scaled ABE: design d_labes 2013-03-16 20:10
      • N=24, 48 d_labes 2013-03-18 08:11
        • adaptive design without adjustment martin 2013-03-25 20:47
          • α adjustment? Helmut 2013-03-26 15:21
            • iteratively adjusted alpha martin 2013-03-26 16:19
              • throw away our sample size tables? Helmut 2013-03-26 18:02
                • if real martin 2013-03-26 19:44
                  • regulators don’t care? Helmut 2013-03-26 21:18
                • adjusting α Helmut 2013-08-11 16:19
                  • missing letter apapanas 2024-10-31 06:02
                    • PowerTOST: sampleN.scABEL.ad() Helmut 2024-10-31 08:41
                      • PowerTOST: sampleN.scABEL.ad() apapanas 2024-11-08 10:48
                        • Molins et al. (2017) Helmut 2024-11-08 14:34
              • target α in sim’s? Helmut 2013-03-27 15:38
                • target α in sim’s?martin 2013-03-27 16:36
                  • If it is real: results Helmut 2013-03-28 23:20
                • having alpha martin 2013-03-28 15:08
                  • fixed swr Helmut 2013-03-28 23:34
                    • fixed swr martin 2013-03-29 15:07
                      • Yes but no but yes but no but… Helmut 2013-03-29 16:10