Bioequivalence and Bioavailability Forum

the unknown x [Power / Sample Size]

posted by Helmut  – Vienna, Austria, 2013-02-11 15:40 (4519 d 13:37 ago) – Posting: # 10002
Views: 10,872

Dear Detlew!

❝ Can you give me a statement on the validity of power.scABEL() and sampleN.scABEL()?

Cross-validating two simulations?

❝ Maybe some of the differences in case of regulator="FDA" are due to the widened ABEL approach instead of the approach via the linearized SABE criterion and its 95% upper confidence limit <0.

Yes, may be another cause.

❝ Again: Coming soon ... or later ...

Relax.

❝ But if you ask them: Ask in this respect if they have used "The unknown x" used in the SAS code of the progesterone guidance in their implementation of the linearized SABE criterion. I haven't found any hint in their papers on HVD/HVDP regarding such a 'correction' for the upper CI part of the point estimator.

Right guess, IMHO. Remember this thread? I’m short in time right now; if you want I can give you their e-mail addresses and you do it yourself.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• Sample size for RSABE Anu 2013-02-01 07:01 [Power / Sample Size] 
  • Sample size for RSABE d_labes 2013-02-01 09:46
    • Sample size for RSABE Anu 2013-02-07 06:58
      • No analytic solution! Helmut 2013-02-07 12:32
        • Coming soon ... d_labes 2013-02-08 11:57
          • Wow! Helmut 2013-02-08 12:19
            • Wow! Anu 2013-02-09 09:20
              • read… Helmut 2013-02-09 09:35
            • Bigamist d_labes 2013-02-09 18:11
              • Some testing (Part I) Helmut 2013-02-10 18:35
              • Some testing (Part II) Helmut 2013-02-11 01:00
                • Power testing d_labes 2013-02-11 12:03
                  • the unknown xHelmut 2013-02-11 14:40
                • Unequal CVs d_labes 2013-02-15 08:47
                  • Typo Helmut 2013-02-15 13:01