Log in
RegisterSample Size and CV for Replicate Design [Power / Sample Size]
Hi!
I'm completely new to the area of BE/BA studies.
My question concerns performing a sample size calculations for a cross over replicate study.
In particular,
I'm told that the intra-subject variability, expressed as %CV of a measured response is expected to be 35%. I'm asked to find the sample size in order to have 80% confidence that the estimated CV% is larger than 30%. Assume I'm planning to do a 2x4 Crossover, Replicate design. That is, I will be looking at TRTR and RTRT.
I'm completely lost on how to approach the question. Any direction or guidance in answering this particular question will be much appreciated. I have access to SAS and R. Please advise.
I'm completely new to the area of BE/BA studies.
My question concerns performing a sample size calculations for a cross over replicate study.
In particular,
I'm told that the intra-subject variability, expressed as %CV of a measured response is expected to be 35%. I'm asked to find the sample size in order to have 80% confidence that the estimated CV% is larger than 30%. Assume I'm planning to do a 2x4 Crossover, Replicate design. That is, I will be looking at TRTR and RTRT.
I'm completely lost on how to approach the question. Any direction or guidance in answering this particular question will be much appreciated. I have access to SAS and R. Please advise.
Complete thread:
- Sample Size and CV for Replicate DesignJamesmartinn 2011-11-26 20:22 [Power / Sample Size]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Sample Size and CV for Replicate Design ElMaestro 2011-11-26 22:38
- Sample Size and CV for Replicate Design Jamesmartinn 2011-11-26 23:52
- Sample Size and CV for Replicate Design ElMaestro 2011-11-27 00:43
- Sample Size and CV for Replicate Design Jamesmartinn 2011-11-27 00:50
- Sample Size and CV for Replicate Design ElMaestro 2011-11-27 01:24
- Sample Size and CV for Replicate Design Jamesmartinn 2011-11-27 01:50
- Strange questions… Helmut 2011-11-27 04:47
- Strange questions… Jamesmartinn 2011-11-27 14:43
- Misusing PowerTOST for superiority? Helmut 2011-11-27 17:46
- Strange questions… ElMaestro 2011-11-27 15:14
- Strange questions… Helmut 2011-11-27 18:07
- Strange questions… Jamesmartinn 2011-11-27 14:43
- Strange questions… Helmut 2011-11-27 04:47
- Sample Size and CV for Replicate Design Jamesmartinn 2011-11-27 01:50
- Sample Size and CV for Replicate Design ElMaestro 2011-11-27 01:24
- Sample Size and CV for Replicate Design Jamesmartinn 2011-11-27 00:50
- Sample Size and CV for Replicate Design ElMaestro 2011-11-27 00:43
- Sample Size and CV for Replicate Design Jamesmartinn 2011-11-26 23:52
- Sample Size and CV for Replicate Design ElMaestro 2011-11-26 22:38
Ing. Helmut Schütz