Bioequivalence and Bioavailability Forum • Tlag

Tlag - subtleties [NCA / SHAM]

posted by d_labes – Berlin, Germany, 2010-03-03 10:23 (5955 d 22:55 ago) – Posting: # 4850
Views: 13,349

Dear all,

beside the discussion we had already in this thread about some variants of defining Tlag I came across some data which made me wondering.

Here an example:


planTime time   CStr   Conc.

     0.0  0.0  <LLOQ   0.00

     0.5  0.5  12.82  12.82

     1.0  1.0  <LLOQ   0.00

     1.5  1.5  <LLOQ   0.00

     2.0  2.0 120.51 120.51

     2.5  2.5 247.52 247.52

     3.0  3.0  99.21  99.21

     3.5  3.5  76.85  76.85

     4.0  4.0 160.08 160.08

     6.0  6.0  35.26  35.26

... (truncated)

LLOQ was 9.6 ng/mL in that study.

My questions:

What do you think where to locate Tlag? Between 0 and 0.5 h or between 1.5 and 2 h?
Is it reasonable to state a definition like:
Tlag was defined as the time prior to (or at the first of) two consecutive Concentrations >LLOQ?
Do you know of any software which has implemented such?

—
Regards,

Detlew

Complete thread:

Tlag - subtletiesd_labes 2010-03-03 09:23 [NCA / SHAM]
- Tlag - subtleties ElMaestro 2010-03-03 10:49
  - Tlag - R qualified d_labes 2010-03-03 13:44
- Tlag - subtleties Helmut 2010-03-03 13:55
  - Tlag - subtleties d_labes 2010-03-03 14:31