Bioequivalence and Bioavailability Forum

AUC(0-tlast) or AUC(0-72h)? [NCA / SHAM]

posted by d_labes  – Berlin, Germany, 2011-11-23 16:42 (4911 d 04:55 ago) – Posting: # 7702
Views: 16,102

Dear Oiinkie!

If you talk about AUC(0-tlast) your CRO has taken the right strategy.
See this rather long thread with Helmut's fine explanation about various types of AUC calculations.

If you talk about truncated area calculation AUC(0-72h) you will surely find this thread interesting. Although rather lengthy .

Hope this helps.

Complete thread:

• AUC(0-t): how to treat BLQ values? Oiinkie 2011-11-23 14:58 
  • AUC(0-tlast) or AUC(0-72h)?d_labes 2011-11-23 15:42
  • AUC(0-72): estimate? Helmut 2011-11-23 16:09
    • OT - Non-existence of conc=0 d_labes 2011-11-24 09:21
      • OT - Non-existence of conc=0 Helmut 2011-11-24 17:28
        • Off topic - Homeopathy d_labes 2011-11-25 08:46
    • AUC(0-72): estimate? Oiinkie 2011-12-05 14:25