Calculation of AUCt [NCA / SHAM]

posted by yckim – 2007-11-27 03:46 (5967 d 02:43 ago) – Posting: # 1334
Views: 29,329

Hi, its very nice to meet you.
The informations from this forum are very helpful. I very appreciate it.

I have a question.
how do you calculate the AUCt and do statistical analysis if there are concentrations below LOQ (at early or late sampling point)? As I know, the 't' time in AUCt should be the same time. Someone recommend to make it zero in the early time. And they also recommend to delete it in the late time to calculate the AUCinf. Is it meaningful to do statistical analysis of AUCt with different 't' value? Please let me know how to proceed the study in such a case.

Sorry for the poor english. ^^
Thank you.

Yu Chul Kim


Edit: Category changed. [Helmut]

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,636 registered users;
112 visitors (0 registered, 112 guests [including 6 identified bots]).
Forum time: 06:29 CET (Europe/Vienna)

With four parameters I can fit an elephant,
and with five I can make him wiggle his trunk.    John von Neumann

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5