Bioequivalence and Bioavailability Forum • MRT and Gravity duration

MRT and Gravity duration [NCA / SHAM]

posted by mittyri – Russia, 2020-06-15 00:24 (1828 d 18:29 ago) – Posting: # 21539
Views: 10,951

Dear Astea,

❝ MRT is a most common PK parameters that compels to look at the AUMC. There existed approaches⁴ to use MRT instead of T_1/2 in order to choose the appropriate washout period.

Just my 2 cents regarding MRT. You cannot estimate it for non-IV ways of administration. For non-IV that parameter is called 'gravity duration', since includes both MIT and MRT. See here for discussion.

—
Kind regards,
Mittyri

Complete thread:

Fantastic PK parameters and where to find them Astea 2020-06-12 14:22
- Fantastic post ?? Helmut 2020-06-12 16:23
  - Rattleback Astea 2020-06-13 10:17
    - Chatter Helmut 2020-06-13 12:28
      - Reinventing the Hula-Hoop Astea 2020-06-16 01:33
        
        Hula-Hoop references Helmut 2020-06-16 13:07
        
        Prof. Keller vs. Yamaoka mittyri 2020-06-17 14:28
        
        SHAM(e) math Astea 2020-06-23 14:41
        
        SHAM(e) math Helmut 2020-06-23 15:55
        
        OT: Möbius strip Astea 2020-06-23 21:41
        
        OT: Möbius strip Helmut 2020-06-24 11:29
- More stuff Helmut 2020-06-13 15:28
- MRT and Gravity durationmittyri 2020-06-14 22:24
- Fantastic PK parameters and where to find them ElMaestro 2020-06-16 09:46
  - Cauchy distribution mittyri 2020-06-16 10:54
    - Cauchy distribution Helmut 2020-06-16 13:14
    - Cauchy distribution ElMaestro 2020-06-20 10:33
      - noncentral normal ratio mittyri 2020-06-20 23:04