least square mean calculation [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2010-08-18 16:15 (5780 d 04:42 ago) – Posting: # 5803
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Dear Bharat,

please search the forum before posting. What about this thread (and linked examples)?

❝ 1. While doing calculations with same formula, i am getting correct values for AUCt, Cmax but for AUCinf i am getting different values.


This is strange. Are you sure that you have complete data for AUCinf?
Maybe you have complete datasets for AUCt, Cmax and are calculating geometric means instead of adjusted (=LSM) means in all cases. Remember that simple mean = adjusted mean only for complete (balanced) datasets. Please check.

❝ 3. Please suggest me a book especially for statistical part of PK?


See this post. Newer editions of some textbooks are published as of today.
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