Bioequivalence and Bioavailability Forum • Mean calculation method in unbalanced cross-over study

Mean calculation method in unbalanced cross-over study [Software]

posted by yckim – 2008-05-27 17:04 (6248 d 07:59 ago) – Posting: # 1874
Views: 10,700

Dear all,

I found the difference of mean calculation method between equivtest 1.0 and 2.0. Equivtest 1.0 calculates (mean_seq1+mean_seq2)/2 instead of {(mean_seq1*n1)+(mean_seq2*n2)}/(n1+n2). The company confirmed Equivtest 2.0 is right. Which is the right one in your opinion? Is the other method absolutely wrong? I would also like to know the theoretical basis.

I look forward to your reply.
Best regards,

Yu Chul Kim
Korea, Republic of

Complete thread:

Mean calculation method in unbalanced cross-over studyyckim 2008-05-27 15:04 [Software]
- EquivTest v1 / v2 / PK Helmut 2008-05-27 15:41
  - EquivTest v1 / v2 / PK yckim 2008-05-28 01:39
    - Weighted mean Helmut 2008-05-28 11:55
      - Least square mean d_labes 2008-05-28 16:35
        
        Least square mean yckim 2008-06-03 07:46
        
        Least square mean JPL 2008-06-03 09:10
        
        Least square mean vish14184 2008-06-04 06:54
        
        Least square mean JPL 2008-06-04 08:44