Bioequivalence and Bioavailability Forum • Lag time in WinNonlin

Lag time in WinNonlin - bug or feature? [Software]

posted by Helmut – Vienna, Austria, 2008-05-26 17:26 (6592 d 07:38 ago) – Posting: # 1872
Views: 15,443

Dear all,

I just discovered another nice one.

Quoting WinNonlin’s 5.2 online help (Noncompartmental analysis > Plasma or serum data > Table B-3.):
Tlag Extravascular input (model 200) only. Tlag is the time prior
to the first measurable (non-zero) concentration.

Beware that non-zero concentration must be taken literally for all other values, i.e., if you have values prior to the first measurable coded as ‘Missing’ or ‘BQL’ or any other non-numeric value, WinNonlin will come up with a Tlag of zero!
Example:


+-------+---------+-------+-------+

| time  | code 1  | code 2| =zero |

+-------+---------+-------+-------+

|  0.00 | Missing |  BQL  |  0    |

|  0.25 | Missing |  BQL  |  0    |

|  0.50 | Missing |  BQL  |  0    |

|  0.75 | Missing |  BQL  |  0    |

|  1.00 | Missing |  BQL  |  0    |

|  1.5  |  10.5   | 10.5  | 10.5  |

|  2.0  |  15.9   | 15.9  | 15.9  |

|  2.5  |  18.4   | 18.4  | 18.4  |

|  3.0  |  19.4   | 19.4  | 19.4  |

|  4    |  19.4   | 19.4  | 19.4  |

|  6    |  17.0   | 17.0  | 17.0  |

|  9    |  13.4   | 13.4  | 13.4  |

| 12    |  10.6   | 10.6  | 10.6  |

| 16    |   7.68  |  7.68 |  7.68 |

| 24    |   4.05  |  4.05 |  4.05 |

| 36    |   1.55  |  1.55 |  1.55 |

+-------+---------+-------+-------+

| Tlag  |   0     |  0    |  1.5  |

(see Edit below)
+-------+---------+-------+-------+

If you want to get correct results you must recode your values first (Tools > Status Codes)!

Edit: See this post. WinNonlin's result for the third column is 1.0 (in agreement with the manual).

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Complete thread:

Lag time in WinNonlin - bug or feature?Helmut 2008-05-26 15:26
- Lag time in WinNonlin - bug or feature? d_labes 2008-05-29 16:47
  - WinNonlin <--> Kinetica... / Survey Helmut 2008-05-29 20:03
    - Tlag d_labes 2008-05-30 08:12
    - First time lag time d_labes 2009-02-02 12:48
      - First time lag time Helmut 2009-02-02 13:08
        
        lag time paper d_labes 2009-02-02 13:42
  - Lag time in WinNonlin - bug or feature? SDavis 2009-02-04 12:49
    - Lag time in WinNonlin - bug or feature? Helmut 2009-02-04 13:05