Bioequivalence and Bioavailability Forum • Wow!

Wow! [Power / Sample Size]

posted by Helmut – Vienna, Austria, 2013-02-08 13:19 (4462 d 23:49 ago) – Posting: # 9993
Views: 10,666

Dear Detlew!

❝ No need to set up your own simulations. Just let PowerTOST do the job :cool: :

❝ And the best of all: computational time for each step approx. 1-2 sec for 1E+06 sims, believe it or not :yes: .

Do you want to marry me? The community will love you for that! Opens even the door for two-stage simulations where the intermediate power/sample size was the actual show-stopper.

❝ In case of regulator="FDA" the sample size is only approximate since the BE decision method via widened BE limits is not exactly what is expected by the FDA. But the two Laszlos state that the scABEL method should be 'operational' equivalent to the FDA method. Thus the sample size should be comparable.

Agree. Remember this one? Somewhere in electronic nirvana I have presentations by Donald Schuirmann showing scaled limits ‘for demonstrational purposes’ as well.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:

Sample size for RSABE Anu 2013-02-01 07:01
- Sample size for RSABE d_labes 2013-02-01 09:46
  - Sample size for RSABE Anu 2013-02-07 06:58
    - No analytic solution! Helmut 2013-02-07 12:32
      - Coming soon ... d_labes 2013-02-08 11:57
        
        Wow!Helmut 2013-02-08 12:19
        
        Wow! Anu 2013-02-09 09:20
        
        read… Helmut 2013-02-09 09:35
        
        Bigamist d_labes 2013-02-09 18:11
        
        Some testing (Part I) Helmut 2013-02-10 18:35
        Some testing (Part II) Helmut 2013-02-11 01:00
        
        Power testing d_labes 2013-02-11 12:03
        
        the unknown x Helmut 2013-02-11 14:40
        
        Unequal CVs d_labes 2013-02-15 08:47
        
        Typo Helmut 2013-02-15 13:01