Bioequivalence and Bioavailability Forum • AND or OR, that’s the question

AND or OR, that’s the question [Power / Sample Size]

posted by chrisk – 2022-08-11 00:00 (1408 d 17:15 ago) – Posting: # 23215
Views: 11,280

Hi Helmut,
Thanks again for this explanation.

After some thoughts, I am wondering if the sample size estimation only considers one comparison. I found an old following post regarding this topic.

If we are considering both T1=R and T2=R, perhaps, we need to look at the bivariate distribution of the two test statistics when looking at the power. And these should be correlated as well, which makes things complicated. I am maybe missing something and was wondering if you could enlighten me on this subject.

Thank you sincerely!

Complete thread:

Sample size for 3-way crossover chrisk 2022-08-09 18:55
- Sample size for 3-way crossover Helmut 2022-08-10 11:30
  - Sample size for 3-way crossover chrisk 2022-08-10 15:24
    - AND or OR, that’s the question Helmut 2022-08-10 15:58
      - AND or OR, that’s the question chrisk 2022-08-10 17:46
        
        AND or OR, that’s the question Helmut 2022-08-10 20:59
        
        AND or OR, that’s the questionchrisk 2022-08-10 22:00
        
        AND or OR, that’s the question Helmut 2022-08-11 15:25
        
        AND or OR, that’s the question chrisk 2022-08-12 16:02
        
        The unknown ρ Helmut 2022-08-17 15:04