AngusMcLean
★★  

USA,
2017-01-05 21:45
(edited by Ohlbe on 2017-01-05 22:38)

Posting: # 16933
Views: 5,518
 

 Concerta individual profiles [Study Per­for­mance]

Concerta is a well-known modified release formulation of methylphenidate. Routinely one sees mean plasma concentration time information from studies in the literature. I am looking for a reference to a publication where individual plasma concentration information is reported either as individual profiles or individual plasma concentration time values. My interest lies in the variability in individual profile shape.

Angus


Edit: subject line changed to lower case. Please don't SHOUT ! Please also check the forum policy under "Be nice!" [Ohlbe].
Helmut
★★★
avatar
Homepage
Vienna, Austria,
2017-01-06 01:09

@ AngusMcLean
Posting: # 16934
Views: 4,927
 

 Concerta individual profiles

Hi Angus,

» I am looking for a reference to a publication where individual plasma concentration information is reported either as individual profiles or individual plasma concentration time values.

I don’t know any… Maybe John can help?

» My interest lies in the variability in individual profile shape.

To give you an idea, one of mine (18 male subjects, Concerta 36 mg, fed state [normal breakfast]; d-MPH base by enantio­selective GC/MS, LLOQ 49 pg/mL):

[image]

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Mahesh M
★    

India,
2017-01-06 08:05

@ Helmut
Posting: # 16935
Views: 4,773
 

 Concerta individual profiles

Hi,

Please see below link hope it will help you.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317218/

Regards


Edit: Yet another one not giving individual data Angus is looking for. SCNR [Helmut]
AngusMcLean
★★  

USA,
2017-01-06 14:23

@ Helmut
Posting: # 16936
Views: 4,741
 

 Concerta individual profiles

Helmut: Thank you. Your data set as a spaghetti plot looks quite good, but it is difficult to find individual data sets.

» [image]
Helmut
★★★
avatar
Homepage
Vienna, Austria,
2017-01-06 17:19

@ AngusMcLean
Posting: # 16937
Views: 4,765
 

 Concerta individual profiles

Hi Angus,

» Your data set as a spaghetti plot looks quite good, but it is difficult to find individual data sets.

I know. Sorry, I can’t disclose subjects’ data.

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
nobody
nothing

2017-01-07 20:32

@ Helmut
Posting: # 16939
Views: 4,672
 

 Concerta individual profiles

Hi!

When I was youngerTM we used sumfink like this do get to the data

http://quadtechassociates.com/freeware.html

(or related Excel scripts)

SCNR :=)

Kindest regards, nobody
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