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RegisterOrouboros mixed up [RSABE / ABEL]
Dear Helmut!
Oh, oh the orouboros has beaten again!
I must confess that I had not understand this paper at all, thus being less than an amateur
("Blutiger Laie" = raw recruit
).
Too bad I do not own WinNonlin.
Can you eventually show some output of this method?
What do you think about an adaption of
J.-P. Liu
Use of the repeated cross-over design in assessing bioequivalence
Statist. Med. 14, 1067-1078 (1995)
It has ANOVA tables but Liu term his model underlying the analysis "Mixed"!
Mixed effects for subject and subject*formulation interaction.
Without mixed effects the corresponding F-Tests would be others, I think.
Oh, oh the orouboros has beaten again!
❝ ... But as a statistical amateur I don't get the point looking at the referred paper:
❝ Hsuan FC, Reeve R. Assessing individual bioequivalence with high-order cross-over designs: a unified procedure. Stat Med. 2003;22:2847–60.
I must confess that I had not understand this paper at all, thus being less than an amateur
("Blutiger Laie" = raw recruit
).❝ The method we proposed here has been implemented in a Pharsight™ product, WinNonlin® (version 3.2 or later).
Too bad I do not own WinNonlin.
Can you eventually show some output of this method?
What do you think about an adaption of
J.-P. Liu
Use of the repeated cross-over design in assessing bioequivalence
Statist. Med. 14, 1067-1078 (1995)
It has ANOVA tables but Liu term his model underlying the analysis "Mixed"!
Mixed effects for subject and subject*formulation interaction.
Without mixed effects the corresponding F-Tests would be others, I think.
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- EMA: ANOVA and replicate studies d_labes 2010-03-05 10:51 [RSABE / ABEL]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- EMA: ANOVA and replicate studies Helmut 2010-03-05 14:17
- Orouboros mixed upd_labes 2010-03-09 09:33
- Orouboros mixed up Helmut 2010-03-09 14:55
- Liu ANOVA PtC d_labes 2010-03-11 11:07
- A walk on the wild side - the Bear way d_labes 2010-03-26 14:01
- New adventures from the Bear way d_labes 2010-03-29 16:17
- New adventures from the Bear way ElMaestro 2010-03-29 17:26
- Posology Helmut 2010-03-29 18:41
- Lost on the Bear way d_labes 2010-03-30 09:20
- Lost on the Bear way ElMaestro 2010-03-30 16:01
- Nice looking three-headed hydra mutant d_labes 2010-04-01 15:20
- Lost on the Bear way ElMaestro 2010-03-30 16:01
- Lost on the Bear way d_labes 2010-03-30 09:20
- Posology Helmut 2010-03-29 18:41
- New adventures from the Bear way ElMaestro 2010-03-29 17:26
- New adventures from the Bear way d_labes 2010-03-29 16:17
- Orouboros mixed up Helmut 2010-03-09 14:55
- Orouboros mixed upd_labes 2010-03-09 09:33
- EMA: ANOVA and replicate studies ElMaestro 2010-03-05 23:02
- Prayers quest d_labes 2010-03-09 09:02
- Go for the referral ElMaestro 2010-03-09 19:02
- Prayers quest d_labes 2010-03-09 09:02
- EMA: ANOVA and replicate studies yjlee168 2010-03-08 03:23
- R: aov(), lm() and what does it mean? d_labes 2010-03-09 08:52
- EMA: ANOVA and replicate studies Helmut 2010-03-05 14:17
Ing. Helmut Schütz