Bioequivalence and Bioavailability Forum • Proc Mixed FA0(1) for partial replicate

Proc Mixed FA0(1) for partial replicate [RSABE / ABEL]

posted by ElMaestro – Denmark, 2013-08-05 19:19 (4347 d 10:56 ago) – Posting: # 11211
Views: 10,110

Hello Wolfgang,

❝ Within the same subject, we have, for the first random statement:

❝ – the variance of an R observation is a²+X

❝ – the variance of a T observation is b²+c²+Y

❝ – the covariance of two different R observations is a²

❝ – the covariance of two different T observations is b²+c²

❝ – the covariance of an R and a T observation is a*b

❝

❝ For the RTRT/TRTR design, this works well.

I am no statistician, so I don't know what I am talking about here. That holds true for a lot of my life's other elements, too.
Can we possibly discuss the model on basis of within(w)- and between(b)-sigmas?

I would think that V (=ZGZ^t+R) should look like this:

the variance of an R observation is s²_b,R+s²_w,R
the variance of a T observation is s²_b,T+s²_w,T
the covariance of R observations is s²_b,R
the covariance of T observations is s²_b,T
optional: the covariance of a mixed observation is "q", which expresses a correlation of the between-sigmas.

No?

—
Pass or fail!
ElMaestro

Complete thread:

RSAB model overspecified Wolfgang 2013-08-05 14:37 [RSABE / ABEL]
- RSAB model overspecified jag009 2013-08-05 15:35
- Proc Mixed FA0(1) for partial replicate d_labes 2013-08-05 15:59
  - Proc Mixed FA0(1) for partial replicate Wolfgang 2013-08-05 16:24
    - Proc Mixed FA0(1) for partial replicateElMaestro 2013-08-05 17:19
      - Proc Mixed FA0(1) for partial replicate Wolfgang 2013-08-06 08:35
        
        Proc Mixed FA0(1) for partial replicate ElMaestro 2013-08-06 10:34
    - Proc Mixed FA0(1) for partial replicate d_labes 2013-08-06 10:30
      - FA0(1) for partial replicate in Phoenix Helmut 2013-08-07 15:13
        
        FA0(1) for partial replicate in SAS d_labes 2013-08-08 09:42
        FA0(1) for partial replicate in Phoenix lhughes 2013-08-30 15:17
        
        FA0(1) in PHX: works (& more questions) Helmut 2013-08-30 17:07