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RegisterSimvastatin Cmax [Study Performance]
Bioequivalance study of Simvastatin.
Please guide us on the justification for lower T/R ratio of Cmax value (65%) for Simvastatin when other parameters like AUC(0-t) & AUC(0-inf) are complying. Also the metabolite -beta hydroxyacid of Simvastatin is complying the 90% confidence for Cmax, AUC(0-t), AUC(0-inf).
Edit: Category changed. See also the policy. [Helmut]
Please guide us on the justification for lower T/R ratio of Cmax value (65%) for Simvastatin when other parameters like AUC(0-t) & AUC(0-inf) are complying. Also the metabolite -beta hydroxyacid of Simvastatin is complying the 90% confidence for Cmax, AUC(0-t), AUC(0-inf).
Edit: Category changed. See also the policy. [Helmut]
Complete thread:
- Simvastatin Cmaxdr suresh gidwani 2010-08-10 12:24 [Study Performance]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Simvastatin Cmax Srinetram 2010-08-11 14:05
- Simvastatin = prodrug Helmut 2010-08-12 16:35
- Simvastatin = prodrug dr suresh gidwani 2010-08-16 06:28
- Simvastatin = prodrug Helmut 2010-08-12 16:35
- Simvastatin Cmax Srinetram 2010-08-11 14:05
Ing. Helmut Schütz