baseline-corrected bioequivalence [General Sta­tis­tics]

posted by lizhao – US, 2014-11-06 23:19 (3898 d 23:41 ago) – Posting: # 13835
Views: 5,956

If a PD endpoint is an endogenous hormone in human body. The PD metric is the change from baseline after taking the medicine. And it is also the PD metric is a concentration, so I should log-transform it.

Then should I use ln(post_treatment-baseline) as the bioequivalence metric?

Thanks

Edit: Please follow the Forum’s policy. [Helmut]

Complete thread:

UA Flag
Activity
 Admin contact
23,430 posts in 4,931 threads, 1,674 registered users;
38 visitors (0 registered, 38 guests [including 12 identified bots]).
Forum time: 00:01 CEST (Europe/Vienna)

To know that we know what we know,
and to know that we do not know what we do not know,
that is true knowledge.    Nicolaus Copernicus

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5