Bioequivalence and Bioavailability Forum

If a PD endpoint is an endogenous hormone in human body. The PD metric is the change from baseline after taking the medicine. And it is also the PD metric is a concentration, so I should log-transform it.

Then should I use ln(post_treatment-baseline) as the bioequivalence metric?

Thanks

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Edit: Please follow the Forum’s policy. [Helmut]