drcampos
★    

Brazil,
2007-07-25 19:21
(6557 d 21:35 ago)

Posting: # 940
Views: 5,736
 

 truncated AUC [NCA / SHAM]

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Dear Helmut,

Articles and Guidances have said that the use of truncated area under the curve could be a significant advantage for BE studies of drugs with long half-lives and low intrasubject variability. So, I would like to know why is not truncated AUC a good option to high intrasubject variability drug?

Regards,

Daniel Rossi de Campos
Brazil
 
Helmut
★★★
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Vienna, Austria,
2007-07-25 19:39
(6557 d 21:17 ago)

@ drcampos
Posting: # 941
Views: 4,473
 

 truncated AUC

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Dear Daniel,

I don’t see any reason why a truncated AUC should not be applied for a HVD/HVDP.
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