(3978 d 23:11 ago)
Posting: # 8521
I really need your help about aplication of Loo Riegelman and deconvolution to calculate the fraction absorbed. I have spent so much time to understand about that, Please tell me the step by step calculation of those equation. Thank you very much.
(3967 d 20:19 ago)
Posting: # 8584
Loo-Riegelman PK model assumes two-compartment PK. I think you may need to refine your question a little as to what you need clarifying.
Phoenix (and WNL 5.x) have detailed example datasets and Guides;
C:\Program Files (x86)\Pharsight\Phoenix\application\Examples
to help step you through using these functions. And of course there is our own software forum (login required).
Edit: Extranet linked. [Helmut]
Senior Scientific Trainer, Certara™
(3870 d 20:48 ago)
(edited by Ohlbe on 2012-08-23 14:22)
Posting: # 9096
sorry for a late response but i think for loo-riegelman deconvolution you should have a look at book of Gibaldi and Perrier pharmacokinetics 2nd edition page no. 155- 162
provided parameters like
Ke or K10;
you can calculate by using following equations:-
Hope it will work for you
Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Ohlbe]
(986 d 19:20 ago)
Posting: # 21712
Thank you for the reference and method explanation for deconvulation using loo riegelman method.
But I have stucked somewhere at the last time point as per the example given in the reference.
The %Absorbed value calculated by me is not matching with the value given and calculated in reference for last time point only.
So I think I am missing some parts like any assumption or hypothesis for consideration during the calculation for last time point.
Please help me to solve the calculation for last time point.
Thanks and Regards