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venu ☆ Mumbai, India, 2007-02-14 06:27 (6278 d 17:02 ago) Posting: # 517 Views: 6,120 |
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Hi, Please throw some light on data entry, data format, pharmacokinetic and statistical analysis for urine concentration pharmacokinetic data. Is the analysis for urine concentration PK data different from plasma/serum concentration PK data? Venu — Best Regards, Ms. Vandana Panchal Biostatistician Mumbai India |
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drshiv ★ India, 2007-02-25 16:16 (6267 d 07:13 ago) (edited by HS on 2007-02-25 19:06) @ venu Posting: # 538 Views: 4,868 |
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Hi Venu, To do urine concentration pharmacokinetic data, you should use cumulative urinary excretion data. You can find a good example in the book- Pharmacokinetics by Milo Gibaldi, Marcel Dekker is the publisher (see appendix which is dedicated for such calculation explanations in the book) Yes it is different to the pharmacokinetics analysis using urinary data. Dr. Shiv Edit: Full quote removed. [HS] |
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Jaime_R ★★ Barcelona, 2007-02-26 12:50 (6266 d 10:39 ago) @ drshiv Posting: # 543 Views: 4,799 |
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Dear Dr. Shiv! ❝ To do urine concentration pharmacokinetic data, you should use cumulative urinary excretion data. Yes, perfectly right. I would just add a big caveat: it's necessary to apply the midtime-point - rather than the end of the sampling interval as the independent variable. — Regards, Jaime |
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drshiv ★ India, 2007-02-26 18:35 (6266 d 04:54 ago) @ Jaime_R Posting: # 544 Views: 4,844 |
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Dear Jaime, Thank you for incorporating this info. Now its complete and mid point method is more accurate. Dr. Shiv Edit: Full quote removed. [HS] |
Ing. Helmut Schütz