mamidi.ganesh
●    

2006-09-23 10:41
(6419 d 03:32 ago)

Posting: # 256
Views: 18,968
 

 ANOVA for 3 way cross over design [Software]

Hai to all,
Can anybody tell me how to approach with ANOVA in a 3x3 crossover Bioequivalence study. In the above design can we use Linear model or Mixed model or both by using SAS. Any information or references regarding 3 way crossover kindly let me know.

Thanks
Ganesh
Jaime_R
★★  

Barcelona,
2006-09-23 19:34
(6418 d 18:40 ago)

@ mamidi.ganesh
Posting: # 257
Views: 16,110
 

 SAS (GLM vs. MIXED)

Hi Ganesh,

PROC GLM is for complete data (subjects completed all treatment periods), whereas PROC MIXED is for incomplete (some data are missing), irrespective of the number of treatments.
GLM uses an exact solution, whereas MIXED is iterative; if you have complete data you may use both of them - although GLM is of course faster. ;-)
Hope, that helps.

BTW, what do you mean by 3x3?

Regards, Jaime
mamidi.ganesh
●    

2006-09-25 12:28
(6417 d 01:46 ago)

@ Jaime_R
Posting: # 258
Views: 15,867
 

 SAS (GLM vs. MIXED)

Hi Jaime,

Thanks for u r reply. By the way 3x3 means three treatment three period. can u please suggest me any books or reference sites about this topic.
Jaime_R
★★  

Barcelona,
2006-09-25 13:12
(6417 d 01:02 ago)

@ mamidi.ganesh
Posting: # 260
Views: 15,750
 

 SAS (GLM vs. MIXED)

Hi Ganesh,

❝ Thanks for u r reply.


You are welcome :-)

❝ By the way 3x3 means three treatment three period.

❝ Can u please suggest me any books or reference sites about this topic.


I hope you are planning for 6 sequences! For an explanation and references see Helmut's post.

Regards, Jaime
Helmut
★★★
avatar
Homepage
Vienna, Austria,
2006-10-03 14:49
(6408 d 23:24 ago)

@ mamidi.ganesh
Posting: # 268
Views: 18,189
 

 SAS-Application for BE

Hi Ganesh,

the SAS-application 'EquivEasy' may be helpful.

A description*) and authors' contact details can be downloaded here.

*) V Luzar-Stiffler and C Stiffler
   Equivalence testing the Easy Way
   J Comp Inform Technol - CIT 10, 2002, 3, 233-239

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