Ravi
★    

India,
2008-11-14 09:57
(4605 d 12:16 ago)

Posting: # 2669
Views: 5,959
 

 Prediction of BID data and steady state calculation [Software]

Dear All,

will any one please help me in solving my problem. I am using Winnonlin software for the prediction of bid data from single dose data. How it has to be done and stady state concentration can be predicted from this. It is reported that drug is following linear kinetics and i am using non compartmental analysis for the same, but unable to do the same.


Edit: Category changed. [Helmut]

Thanks & Regards
Ravi Pandey
Helmut
★★★
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Homepage
Vienna, Austria,
2008-11-14 10:38
(4605 d 11:35 ago)

@ Ravi
Posting: # 2670
Views: 5,253
 

 Prediction of BID data and steady state calculation

Dear Ravi!

I gave you already a detailed answer in this post. If you are not happy with nonparametric superposition, you will have to go with compartmental modeling. I’m not in the mood to give all the steps (read the manual first – only if you have specific questions ask again). The steps are:
  • Open your workbook
  • Choose a compiled pharmacokinetic model (for Exp1.pwo it’s model 11: two compartments, no lag time)
  • Start with weights=1 and proceed with other weighting schemes
  • Select the “best” model based on residual plots and (mainly) the minimum AIC (for Exp1.pwo it’s w=1/y2)
  • Create a new workbook, fill in time values in the first column
  • Select PK Model 11, select “Simulate data“
  • Select the number of doses, dosed amounts and dosing times
  • Paste the model parameters from your original fitting
  • Done

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