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Porfirio ☆ 2023-07-18 19:55 (139 d 14:34 ago) Posting: # 23674 Views: 1,083 |
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Hello everyone! I am a beginner on the subject about IVIVC and I have plenty questions. Can somebody help me? Coul you recommend me a step by step course to develop ivivc? I´m trying to develop an example of IVIVC. I have in vitro and in vivo data for an intermediate release (InR) formulation, a slow release (SR), immediate release (IR) and the reference formulation (target). I only have in vitro data of the “test” formulation and I wan to predict its pharmacokinetic parameters. I tried to do it but something was wrong (see images below).
![[image]](img/uploaded/image854.png) ![[image]](img/uploaded/image856.png) My apologies, I think there are many questions, I hope you can help me with some. It is very important for me. Thaks Best regards |
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Helmut ★★★   Vienna, Austria, 2023-07-19 10:54 (138 d 23:36 ago) @ Porfirio Posting: # 23675 Views: 863 |
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— Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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dshah ★★ India/United Kingdom, 2023-07-19 11:44 (138 d 22:46 ago) @ Porfirio Posting: # 23677 Views: 875 |
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Hi Porfirio! ❝ 1. I read in a forum that UIR depends on the number of compartments, but what exactly does it mean? Should I always put 3? If your drug follows one compartment- choose 1, if two compartment- choose 2 and if three compartment- choose 3. ❝ 2. In the validation which one should I put as external or internal? If the data you are using is already used for building IVIVC - then it is internal validation, but if you are using other data that has not been used for IVIVC buildup - then it is external validation. ❝ 3. How do I know if I should put the weibull function or the double weibull function (for example)? Is the fit bond performed before or does the software also perform it? Kindly see the diagnostic and based on AIC value, choose the model. ❝ 4. For weighting, how do I know which one to choose? Kindly see the diagnostic and based on AIC value, choose the model. Regards, Divyen |
Ing. Helmut Schütz