WinnieH ☆ Sweden, 20230104 14:33 (32 d 12:45 ago) Posting: # 23417 Views: 529 

Dear all, I am a new learner and I am trying on understanding the 4way RSABE method SAS code provided by FDA: /*Intermediate analysis – ilat*/ I found some discussion about the S2wr and it is really helpful to me. About the ilat, my understanding is that the model is a simple linear model and the estimate is the least square mean. My R code example is as follows:
mod<lm(ilat~SEQ, dataset) My question is 1) how to interpret x and critbound=(x+y)+sqrt(((boundxx)**2)+((boundyy)**2))? Is there any related explanation about them? 2) Has anyone tried to reproduce this FDA code in R before? I would like to get some hints from you Thank you very much and wish you a happy new year! Bests, Winnie 
Helmut ★★★ Vienna, Austria, 20230104 15:02 (32 d 12:16 ago) @ WinnieH Posting: # 23418 Views: 463 

Hi Winnie, ❝ I am a new learner and I am trying on understanding the 4way RSABE method SAS code provided by FDA: […] ❝ I found some discussion about the S2wr and it is really helpful to me. About the ilat, my understanding is that the model is a simple linear model and the estimate is the least square mean. I don’t speak SAS but isn’t it a restricted maximum likelihood estimate? ❝ My R code example is as follows: […] I’m short in time right now; compare it to Detlew’s script in base R. ❝ My question is 1) how to interpret x and critbound=(x+y)+sqrt(((boundxx)**2)+((boundyy)**2))? Is there any related explanation about them? Haha, ‘the unknown x’. I’m aware of only one reference,* which is – regrettably – not in the public domain.
— Diftor heh smusma 🖖🏼 Довге життя Україна! _{} Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes 
WinnieH ☆ Sweden, 20230104 16:12 (32 d 11:06 ago) @ Helmut Posting: # 23419 Views: 448 

Hi Helmut, Thank you so much for your fast reply! They are very helpful! Best regards, Zhe 