(42 d 17:46 ago)
Posting: # 23410
Hi to everybody,
I have calculated the ISCV% from a replicated BE with the estimated s2wr. For this, I have calculated the standar deviation of the two observations (BE replicated) of each subject, then I have calculated the mean of all SD, and with that mean of SD I have calculated the ISCV% according to the below formula:
CV%= 100*square root(e^s2wr-1)
Can anyone confirm that it is correct?
Thank you so much,
(42 d 14:51 ago)
Posting: # 23411
❝ Can anyone confirm that it is correct?
That’s an approximation (like a model with subject as the only effect).
According to the EMA’s Q&A document we have to fit a linear model of R-data with fixed effects sequence, subject(sequence), period and calculate CVwR from the models’ residual MSE. As usual, you could drop sequence (keep only subject and period).
BTW, from the FDA’s mixed-effects model we could directly get CVwR with
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