Nicolas_2022
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Russia,
2022-08-24 11:49
(600 d 01:45 ago)

Posting: # 23229
Views: 2,145
 

 R code to assess bio­equi­va­lence [Software]

Hi All,

Helmut's lecture at Mumbai in 2012 contains R code that allows to assess BE in 2x2 crossover study (https://bebac.at/lectures/MumbaiWS2012-2.pdf).

Does anybody have R code to assess BE in full replicative studies?:confused:

I am not strong in math so I can't modify current script...:-(
Helmut
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Vienna, Austria,
2022-08-24 12:23
(600 d 01:11 ago)

@ Nicolas_2022
Posting: # 23230
Views: 1,818
 

 package replicateBE

Hi Nicolas,

❝ Does anybody have R code to assess BE in full replicative studies?


The package replicateBE would help. See also the online manual and its vignette. The package was cross-validated against SAS, Phoenix WinNonlin, STATISTICA, SPSS, Stata, and JMP.*

Articles about the background:
  • Schütz H, Tomashevskiy M, Labes D, Shitova A, González-de la Parra M, Fuglsang A. Reference Datasets for Studies in a Replicate Design intended for Average Bioequivalence with Expanding Limits. AAPS J. 2020; 22(2): Article 44. doi:10.1208/s12248-020-0427-6. [image] Open access.

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Nicolas_2022
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Russia,
2022-08-24 13:00
(600 d 00:34 ago)

@ Helmut
Posting: # 23231
Views: 1,776
 

 package replicateBE

Hi Helmut,

Many thanks for updating me with R package but I am fond of programming in visual basic and I'd like to create my own script in basic for my own purposes. ;-)
I managed to make VB code for 2x2 crossover quite quickly with your lecture but I don't know how to modify it for 2x2x4.
Partial designs are not utilized in my practice :-D
Helmut
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Vienna, Austria,
2022-08-24 13:19
(600 d 00:15 ago)

@ Nicolas_2022
Posting: # 23232
Views: 1,815
 

 replicate designs in VB

Hi Nicolas,

❝ […] I am fond of programming in visual basic and I'd like to create my own script in basic for my own purposes. ;-)

❝ I managed to make VB code for 2x2 crossover quite quickly with your lecture but I don't know how to modify it for 2x2x4.


Sorry, no idea. The last time I coded in VB is 20+ years ago. Good luck in rolling out your own code.
At least you can use the package replicateBE for cross-validation. Hint: The data sets in CSV-format are also available at GitHub. The ones of a TRTR|RTRT-design are DSXX.csv, where XX = 01, 06, 08, 09, 1215, 1821, 25, 26, and 29.

❝ Partial designs are not utilized in my practice :-D


Good. Very good!

PS: I moved the thread to the category Software.

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