narra1813
☆    

India,
2022-08-07 17:39
(620 d 17:07 ago)

Posting: # 23207
Views: 1,733
 

 Inactive Glucuronide metabolite [Bioanalytics]

Hi,

Could you please explain if any compound is having inactive glucuronide metabolite and it's Cmax concentration was not available in the public domain. Which concentration need to spike to check the back conversion is happens to parent compound.


Edit: Category changed; see also this post #1[Helmut]

Regards

Narra Narendra Babu
ElMaestro
★★★

Denmark,
2022-08-07 20:05
(620 d 14:41 ago)

@ narra1813
Posting: # 23208
Views: 1,419
 

 Inactive Glucuronide metabolite

Hi narra1813,

❝ Could you please explain if any compound is having inactive glucuronide metabolite and it's Cmax concentration was not available in the public domain. Which concentration need to spike to check the back conversion is happens to parent compound.


If you know the Cmax of parent and there is only a single metabolite, then you can do a worst-case scenario through realising that absent a lot of sorcery (and assuming this isn't endogenous) on a molar basis the metabolite should never reach a higher concentration than the parent when one parent molecule can result in one metabolite molecule. Look up the molar weights and convert mg/mL for parent and metabolite.
It may likely be a vast overkill in terms of realistic concentration, though, but if you do not have anything better to go by, this is the best I can come up with.

Pass or fail!
ElMaestro
professionalr
☆    

India,
2022-08-12 12:56
(615 d 21:50 ago)

@ narra1813
Posting: # 23217
Views: 1,333
 

 Inactive Glucuronide metabolite

Hi Narra,

❝ Could you please explain if any compound is having inactive glucuronide metabolite and it's Cmax concentration was not available in the public domain. Which concentration need to spike to check the back conversion is happens to parent compound.


Did you checked the availability of pharmacokinetic information of that inactive glucuronide metabolite in FDA Accessdata or EMA's Public Assessment Reports, usually you may get the information from the above two.

Thanks,
RP.
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