Imph
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2022-01-23 15:21
(795 d 21:48 ago)

Posting: # 22743
Views: 1,784
 

 Intrasubject coefficient of variation [Power / Sample Size]

Hello,
Please I have a question regarding the within subject coefficient of variation. Is it dose dependent? Can I take a coefficient of variation from a study done on a 500mg dosage and use it to calculate the number of subjects in a trial that will be done on a 1000mg dosage. Thank you in advance.
Helmut
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2022-01-23 15:46
(795 d 21:23 ago)

@ Imph
Posting: # 22744
Views: 1,476
 

 Dose-dependent CV?

Hi Imph,

❝ […] within subject coefficient of variation. Is it dose dependent?


If you have linear PK, generally yes. Otherwise, not necessarily.

❝ Can I take a coefficient of variation from a study done on a 500mg dosage and use it to calculate the number of subjects in a trial that will be done on a 1000mg dosage.


See above.

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Imph
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2022-01-23 15:55
(795 d 21:14 ago)

@ Helmut
Posting: # 22745
Views: 1,378
 

 Dose-dependent CV?

Thank you a lot for your help.

Best regards.


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5[Helmut]
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