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yogeshla ☆ India, 2021-10-18 16:24 (597 d 19:17 ago) Posting: # 22635 Views: 1,943 |
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Hi, Can we do PK modeling or simulation using Phoenix winNonlin/nlme module? If yes can someone elaborate process. I need to simulate PK data observed from 2 studies to predict PK data of future formulation with similar changes. |
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jag009 ★★★ NJ, 2021-10-19 10:04 (597 d 01:37 ago) @ yogeshla Posting: # 22637 Views: 1,580 |
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Hi, ❝ I need to simulate PK data observed from 2 studies to predict PK data of future formulation with similar changes. Are you referring to IVIVC? J |
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yogeshla ☆ India, 2021-10-19 14:37 (596 d 21:04 ago) @ jag009 Posting: # 22640 Views: 1,531 |
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Thanx J, question is related to PK-PD modeling. |
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SDavis ★★  UK, 2021-10-19 13:23 (596 d 22:19 ago) @ yogeshla Posting: # 22638 Views: 1,545 |
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This is definitely possible, either via IVIVC or the model object; There are worked examples in the Help. https://onlinehelp-dev.certara.com/phoenix/8.3/topics/nlmeexfitpkpd.htm#XREF_32183_Fitting_PK_and_PD And there are also some free training materials - look at Help>Phoenix IVIVC tutorial and the other material in Certara University. If you have a specific questions you can try looking or asking on the User forums https://support.certara.com/forums/ or if you have some specific queston you can try emailing [email protected] Simon. — Simon Senior Scientific Trainer, Certara™ [link=https://www.youtube.com/watch?v=xX-yCO5Rzag[/link] https://www.certarauniversity.com/dashboard https://support.certara.com/forums/ |
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yogeshla ☆ India, 2021-10-19 14:36 (596 d 21:05 ago) @ SDavis Posting: # 22639 Views: 1,475 |
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Thanx Simon, Question is related to PK-PD modeling, like wanted to build model using observed PK data linked with git pH value and predict data for future batch. Thanks in advance !! |
Ing. Helmut Schütz