yogeshla
☆    

India,
2021-10-18 16:24
(715 d 03:43 ago)

Posting: # 22635
Views: 2,217
 

 PK simulation in Phoenix [Software]

Hi,

Can we do PK modeling or simulation using Phoenix winNonlin/nlme module? If yes can someone elaborate process. I need to simulate PK data observed from 2 studies to predict PK data of future formulation with similar changes.
jag009
★★★

NJ,
2021-10-19 10:04
(714 d 10:03 ago)

@ yogeshla
Posting: # 22637
Views: 1,809
 

 PK simulation in Phoenix

Hi,

❝ I need to simulate PK data observed from 2 studies to predict PK data of future formulation with similar changes.


Are you referring to IVIVC?

J
yogeshla
☆    

India,
2021-10-19 14:37
(714 d 05:30 ago)

@ jag009
Posting: # 22640
Views: 1,762
 

 PK simulation in Phoenix

Thanx J,

question is related to PK-PD modeling.
SDavis
★★  
Homepage
UK,
2021-10-19 13:23
(714 d 06:45 ago)

@ yogeshla
Posting: # 22638
Views: 1,764
 

 PK simulation in Phoenix

This is definitely possible, either via IVIVC or the model object;

There are worked examples in the Help.

https://onlinehelp-dev.certara.com/phoenix/8.3/topics/nlmeexfitpkpd.htm#XREF_32183_Fitting_PK_and_PD

And there are also some free training materials - look at Help>Phoenix IVIVC tutorial and the other material in Certara University.

If you have a specific questions you can try looking or asking on the User forums https://support.certara.com/forums/

or if you have some specific queston you can try emailing [email protected]

Simon.

Simon
Senior Scientific Trainer, Certara™
[link=https://www.youtube.com/watch?v=xX-yCO5Rzag[/link]
https://www.certarauniversity.com/dashboard
https://support.certara.com/forums/
yogeshla
☆    

India,
2021-10-19 14:36
(714 d 05:31 ago)

@ SDavis
Posting: # 22639
Views: 1,690
 

 PK simulation in Phoenix

Thanx Simon,

Question is related to PK-PD modeling, like wanted to build model using observed PK data linked with git pH value and predict data for future batch.

Thanks in advance !!
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