pharm07
☆    

India,
2021-06-30 05:33
(86 d 06:32 ago)

Posting: # 22438
Views: 540
 

 Calculation of % Liver FPE [PK / PD]

How to estimate liver % FPE from Loo-Riegelman (2-compartment) model deconvolution of oral cp time profile data?


Edit: Category changed; see also this post #1[Helmut]

Regards,
pharm07
Helmut
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Vienna, Austria,
2021-06-30 10:27
(86 d 01:38 ago)

@ pharm07
Posting: # 22441
Views: 460
 

 PBPK

Hi pharm07,

» How to estimate liver % FPE from Loo-Riegelman (2-compartment) model deconvolution of oral cp time profile data?

For Loo-Riegelman you require the ‘true’ elimination from an iv administration. I guess you have it. However, any PK model (and deconvolution based on it) is purely empirical. There is no relationship to physiology.*
Hence, you cannot distinguish between liver first pass and pre-systemic first pass in the gut wall. If you are interested in them, you need PBPK.

[image]
Peters SA. Physiology-Based PK (PBPK). Modeling and Simulations. Wiley, 2012.



  • Did you ever wonder why some drugs have a volume of distribution of hundreds (‼) of liters?

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pharm07
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India,
2021-07-01 16:59
(84 d 19:06 ago)

(edited by pharm07 on 2021-07-02 05:40)
@ Helmut
Posting: # 22448
Views: 420
 

 PBPK

[ No text ]

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pharm07
Helmut
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Vienna, Austria,
2021-07-01 17:09
(84 d 18:56 ago)

@ pharm07
Posting: # 22449
Views: 409
 

 PBPK

Hi pharm07,

» » For Loo-Riegelman you require the ‘true’ elimination from an iv administration. I guess you have it.
» » […] you cannot distinguish between liver first pass and pre-systemic first pass in the gut wall. If you are interested in them, you need PBPK.

» Thanks for your suggestion :-)
»
» Yes, I have an elimination value. Can you support on this, how to calculate? or how to build the model?

Did you bother reading my previous post? You can’t estimate liver first pass with a PK model. If you have – a lot of – money, go for suitable software (SymCyp, GastroPlus). Even then, there is no guarantee that it will work for your drug (I have seen terrific failures).
May I ask: What do you want to achieve?

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Helmut Schütz
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The quality of responses received is directly proportional to the quality of the question asked. 🚮
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