Log in
Register|
pharm07 ☆ India, 2021-06-30 07:33 (708 d 03:49 ago) Posting: # 22438 Views: 1,204 |
|
|
How to estimate liver % FPE from Loo-Riegelman (2-compartment) model deconvolution of oral cp time profile data? Edit: Category changed; see also this post #1. [Helmut] — Regards, pharm07 |
|
Helmut ★★★   Vienna, Austria, 2021-06-30 12:27 (707 d 22:55 ago) @ pharm07 Posting: # 22441 Views: 1,031 |
|
|
Hi pharm07, ❝ How to estimate liver % FPE from Loo-Riegelman (2-compartment) model deconvolution of oral cp time profile data? For Loo-Riegelman you require the ‘true’ elimination from an iv administration. I guess you have it. However, any PK model (and deconvolution based on it) is purely empirical. There is no relationship to physiology.* Hence, you cannot distinguish between liver first pass and pre-systemic first pass in the gut wall. If you are interested in them, you need PBPK.
— Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
![[image]](img/uploaded/image771.png)
|
pharm07 ☆ India, 2021-07-01 18:59 (706 d 16:23 ago) (edited by pharm07 on 2021-07-02 05:40) @ Helmut Posting: # 22448 Views: 1,021 |
|
|
[ No text ] — Regards, pharm07 |
|
Helmut ★★★ Vienna, Austria, 2021-07-01 19:09 (706 d 16:13 ago) @ pharm07 Posting: # 22449 Views: 991 |
|
|
Hi pharm07, ❝ ❝ For Loo-Riegelman you require the ‘true’ elimination from an iv administration. I guess you have it. ❝ ❝ […] you cannot distinguish between liver first pass and pre-systemic first pass in the gut wall. If you are interested in them, you need PBPK. ❝ Thanks for your suggestion ❝ ❝ Yes, I have an elimination value. Can you support on this, how to calculate? or how to build the model? Did you bother reading my previous post? You can’t estimate liver first pass with a PK model. If you have – a lot of – money, go for suitable software (SymCyp, GastroPlus). Even then, there is no guarantee that it will work for your drug (I have seen terrific failures). May I ask: What do you want to achieve? — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Ing. Helmut Schütz