(981 d 11:33 ago)
Posting: # 22287
I want to know that why while auc with in spect Cmax out of it? its means that test has higher dissolution rate everytime, or can cause another thing such as CRO, design of study, bioanalytical method?
(980 d 21:05 ago)
Posting: # 22292
❝ I want to know that why while auc with in spect Cmax out of it? its means that test has higher dissolution rate everytime, …
Only if your drug is in BCS class I or – under certain conditions – in class III, dissolution plays a major rule. If in class II/IV, dissolution is not predictive. There are a manifold of reasons with the absorption rate differs between products. Even if excipients and their amount are identical, differences in the manufacturing process may explain the different absorption.
❝ … or can cause another thing such as CRO, …
❝ … design of study, …
Only if you have problems with a “first point Cmax”.
❝ … bioanalytical method?
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
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(979 d 15:10 ago)
Posting: # 22293
Merhaba Helmut :)