libaiyi ★ China, 2021-02-02 10:39 (1150 d 07:42 ago) Posting: # 22199 Views: 2,175 |
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Dear all, Recently I meet a problem about sample size of high variance drug, normally, we will design a repeated cross-over trial for this kind of drug. But this time it is designed as a parallel study due to some reasons. But the sample size is too much based on 80%-125% BE CI. So my quesion is if we have any method to widen the CI like RSABE in cross-over study? Thank you very mcuh. Sincerely, libaiyi |
ElMaestro ★★★ Denmark, 2021-02-02 12:12 (1150 d 06:09 ago) @ libaiyi Posting: # 22200 Views: 1,723 |
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Hi libaiyi, ❝ (...) So my quesion is if we have any method to widen the CI like RSABE in cross-over study? I don't think there is any authority generally willing to widen the acceptance range in parallel trials involving humans (they'd perhaps do it if you were studying pMDI's in vitro etc). — Pass or fail! ElMaestro |
libaiyi ★ China, 2021-02-02 12:40 (1150 d 05:42 ago) @ ElMaestro Posting: # 22201 Views: 1,702 |
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Get it! Thank you Sir! Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut] |