yjlee168
★★★
avatar
Homepage
Kaohsiung, Taiwan,
2020-10-20 11:53
(1444 d 10:00 ago)

Posting: # 22035
Views: 4,556
 

 bear: it's time to say goodbye [🇷 for BE/BA]

Post reply
Dear Helmut & other members,

❝ [...] PS: Do you plan to implement my [image]-code for ABE of last May in a future release of bear?


Right. If you're talking about the package replicateBE, I have some excuses:
  1. if there is a future release of bear? Nope. No such a plan recently (plz see below).
  2. I did not have the dataset of replicate BE (> two sequences) to test. The dataset can be analyzed from NCA (subj, time, conc, & ...) , not just statistical analysis with final pivotal parameters (Cmax & AUCs) as bundled with replicateBE package. I tried to compose some for the testing purposes, then I gave it up. I asked some users if they could provide such a dataset with no luck. Quite understood.
  3. Some limitations need to be lifted first from the current bear, such as # of sequences & periods. I messed up several times.
  4. ReplicateBE package has been good enough and well illustrated in the Forum or Github. Users should be able to deploy it very easily.
  5. OK, I'm lazy.
It's been a good time for bear in this Forum since 2008 (as far as I can remember). Lots of supports or excellent suggestions come from the members of this Forum. The reasons for bear to say goodbye at this moment are:
  1. it has been stepped down from the official R repository (CRAN) since 2015; so it's not an official package any more;
  2. two dependent packages: gWidgets & gWidgetRGtk2 have been removed/retried from CRAN this year; although users still can run GUI of bear right now, I don't know how long it can sustain anyway. So I will try to use tcltk & tcltk2 packages to re-write bear (GUI part); This is supposed to take a lot of time. At least I have a good start with tcltk & tcltk2 with preinst.r; In summary, bear is supposed to be retired/removed/deprecated if it was among packages of CRAN.
  3. OK, I'm lazy (again).

Finally, I like to thank you all for such long-term supports. Goodbye. 再見/再见。Auf Wiedersehen. Au revoir. さようなら. Прощай. 안녕. Adiós. Αντιο σας. अलविदा.

Edit: Category changed (made a new thread). [Helmut]
—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
 
Helmut
★★★
avatar
Homepage
Vienna, Austria,
2020-10-20 13:30
(1444 d 08:24 ago)

@ yjlee168
Posting: # 22036
Views: 3,997
 

 So sad!

Post reply
Hi Yung-jin,

I moved your post (which was a reply to that one).

❝ ❝ [...] PS: Do you plan to implement my [image]-code for ABE of last May in a future release of bear?

❝

❝ Right. If you're talking about the package replicateBE,…


Nope, I was only talking about the sample size estimation for bear’s ABE.

❝ I have some excuses:…


Sure. I don’t expect that you will implement ABEL in bear. Theoretically you could add importFrom("replicateBE", method.A, method.B) to the NAMESPACE and call the functions from bear. Lot of work cause bear’s coding for treatment, sequence, and period differs from their conterparts in replicateBE.
Datasets for testing are given in CSV-format in the {R installation}/library/replicateBE/extdata/ folder and on GitHub. In [image]’s binary format also on GitHub.

❝ It's been a good time for bear in this Forum since 2008…


Your initial thread contains an amazing number of 67 posts. It still is the record holder in the forum. :-D

Given the work you’ve I done in the last years I don’t think that you are lazy. On the contrary!
Writing [image] packages can be hell and we rarely – if ever – win laurels for it. Only complaints…

If you decide to retire bear or don’t want to develop it further, I can understand that.
Its loyal users will miss it. :crying:

非常感谢 [image]!

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
 
yjlee168
★★★
avatar
Homepage
Kaohsiung, Taiwan,
2020-10-20 15:39
(1444 d 06:14 ago)

@ Helmut
Posting: # 22038
Views: 3,903
 

 So sad!

Post reply
Hi Helmut,

❝ [...]


❝ Nope, I was only talking about the sample size estimation for bear’s ABE.


Yes, I have already included your codes since v2.8.8 released last June.

[image]

Click the pop-down menu of 'I want to do', then select 'sample size estimation'.

[image]

❝ Your initial thread contains an amazing number of 67 posts. It still is the record holder in the forum. :-D


Thank you so much.

❝ If you decide to retire bear or don’t want to develop it further, I can understand that.


I wish I can back with tcltk-built bear soon. Dunno when.
—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
 
Helmut
★★★
avatar
Homepage
Vienna, Austria,
2020-10-20 15:58
(1444 d 05:55 ago)

@ yjlee168
Posting: # 22040
Views: 3,902
 

 THX!

Post reply
Hi Yung-jin,

❝ Yes, I have already included your codes since v2.8.8 released last June.


THX! Since the version-number did not change I missed the update.
[image] v2.8.8 and v2.8.9 work like a charm on [image] v4.0.3.

[image]

❝ ❝ If you decide to retire bear or don’t want to develop it further, I can understand that.

❝

❝ I wish I can back with tcltk-built bear soon. Dunno when.


No worries. At the end of the day it’s a spare time project, right?
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
 
krish85
☆    

India,
2020-10-20 15:01
(1444 d 06:53 ago)

@ yjlee168
Posting: # 22037
Views: 3,918
 

 bear: it's time to say goodbye

Post reply
Dear Yung-jin,

You have always been super helpful and kind.

I sincerely thank you for your support and be there with us whenver required.

Kudos !:thumb up:

And No, You are not lazy...;-)
 
yjlee168
★★★
avatar
Homepage
Kaohsiung, Taiwan,
2020-10-20 15:43
(1444 d 06:11 ago)

@ krish85
Posting: # 22039
Views: 3,887
 

 bear: it's time to say goodbye

Post reply
Dear Krish85,

Thank you too.
—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
 
Astea
★★  

Russia,
2020-10-21 16:36
(1443 d 05:18 ago)

@ yjlee168
Posting: # 22043
Views: 3,837
 

 bear: it's time to say goodbye

Post reply
Dear yjlee168!

It is very sad to read! You're a great programmer! Bear helped us out so many times!!!...

❝ Its loyal users will miss it. :crying:


We'll definetely miss it!:crying:

Hope you'll find the strength to revive Bear in a new quality!
—
"Being in minority, even a minority of one, did not make you mad"
 
yjlee168
★★★
avatar
Homepage
Kaohsiung, Taiwan,
2020-10-21 22:07
(1442 d 23:47 ago)

@ Astea
Posting: # 22044
Views: 3,732
 

 Thanks!

Post reply
Dear Astea,

Thank you too for your input (error report) to bear.

❝ Hope you'll find the strength to revive Bear in a new quality!


OK & thank you again. I will definitely do my best.
—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
 
UA Flag
Activity
 Admin contact
23,240 posts in 4,884 threads, 1,655 registered users;
63 visitors (0 registered, 63 guests [including 9 identified bots]).
Forum time: 21:54 CEST (Europe/Vienna)

The epistemological value of probability theory is based on the fact
that chance phenomena, considered collectively and on a grand scale,
create non-random regularity.    Andrey Kolmogorov

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5