begoña
☆    

Spain,
2020-10-08 12:14
(679 d 09:15 ago)

Posting: # 21976
Views: 1,870
 

 Dextromethorphan [Dissolution / BCS / IVIVC]

I am trying to find information about BCS classification of Dexthrometorphan BrH

Thank you
Sridhar.E
☆    

India,
2020-10-08 12:27
(679 d 09:01 ago)

@ begoña
Posting: # 21978
Views: 1,653
 

 Dextromethorphan

» I am trying to find information about BCS classification of Dexthrometorphan BrH

Hai

Dextromethorphan hydrobromide belongs to the class II of biopharmaceutics classification system (BCS), exhibits low solubility and high permeability.
begoña
☆    

Spain,
2020-10-08 12:35
(679 d 08:53 ago)

@ Sridhar.E
Posting: # 21979
Views: 1,664
 

 Dextromethorphan

» Dextromethorphan hydrobromide belongs to the class II of biopharmaceutics classification system (BCS), exhibits low solubility and high permeability.

Thanks
I read papers where it has classified as Class II, but also I found several publications that describe Dextromehorphan HBr as very high soluble substance.

I was wondering if I could ask for a biowaiver, during the evaluation of an oral product containig dexthrometorphan.


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5[Helmut]
Sridhar.E
☆    

India,
2020-10-08 12:59
(679 d 08:29 ago)

@ begoña
Posting: # 21981
Views: 1,641
 

 Dextromethorphan

» I read papers where it has classified as Class II, but also I found several publications that describe Dextromehorphan HBr as very high soluble substance.

I gone through reviews, I found Dextromehorphan Practically insoluble in water.

The Waiver request of in-vivo testing: 30 mg/600 mg based on acceptable bioequivalence studies on the 60 mg/1200 strength, acceptable dissolution testing across all strengths.


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Ohlbe]
Helmut
★★★
avatar
Homepage
Vienna, Austria,
2020-10-08 12:54
(679 d 08:35 ago)

@ begoña
Posting: # 21980
Views: 1,647
 

 Dextromethorphan: Class II?

Hi begoña,

» I am trying to find information about BCS classification of Dexthrometorphan BrH

doi:10.14499/indonesianjpharm25iss3pp181
https://etd.ohiolink.edu/!etd.send_file?accession=mco1470340367&disposition=attachment

Dif-tor heh smusma 🖖 [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
UA Flag
Activity
 Admin contact
22,305 posts in 4,668 threads, 1,587 registered users;
online 7 (0 registered, 7 guests [including 4 identified bots]).
Forum time: Thursday 21:29 CEST (Europe/Vienna)

On two occasions I have been asked,—“Pray, Mr. Babbage,
if you put into the machine wrong figures,…
will the right answers come out?”
 …
I am not able rightly to apprehend the kind of confusion of ideas
that could provoke such a question.    Charles Babbage

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5